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KMID : 0357919800140020021
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Korean Journal of Pathology
1980 Volume.14 No. 2 p.21 ~ p.30
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Cytologic Study on Microinvasive Squamous Cell Carcinoma of the Uterine Cervix
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Abstract
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Cervico-vaginal smears from 10 patients with microinvasive squamous cell carcinoma
of the cervix confirmed on the histologic examination of the conization or hysterectomy
specimen were retrospectively investigated.
1) The degree of stromal penetration on the histologic examination was estimated as
upper (1 case), middle (4 cases) and lower 1/3 (5 cases) of the mucosa equivalent to
the length of the cervical mucous glands. The cervico-vaginal smears of the 10 patients
obtained prior to the surgical interventions were originally diagnosed as severe dysplasia
(3 cases), microinvasive carcinoma (2 cases) and invasive carcinoma (5 cases) .
2) On the histological examination the covering epithelium of the microinvasive
carcinoma showed a variety of intraepithelial neoplastic changes including dysplasia of
variable degrees and in situ carcinoma in some extend.
3) A cytologic analysis on the smears revealed the cells indicating microinvasion in
9.5%(upper 1/3), 26.4% (middle 1/3) and 17.8% (lower 1/3 stromal invasion) as a
prevalence among the cells screened.
4) The microinvasive carcinoma cells contained cellular abnormalities which varied
somewhat in relation to the depth of penetration. The deeper penetrated the abnormal
cells the more smeared in aggregates. A tumor diathesis was evident in 9 of 10 cases.
The cells with the deepest penetration (lower 1/3) had an irregularly distributed coarse
chromatin and prominent nucleoli, while the abnormal cells with upper 1/3 stromal
penetration had a regularly distributed fine chromatin and no prominent nucleoli.
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